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KMID : 0043319980210010067
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Archives of Pharmacal Research
1998 Volume.21 No. 1 p.67 ~ p.69
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Isolation and Identification of Inhibitory Compounds on TNF- Production from Magnolia fargesii
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Chae Sook-Hee
Kim Pyoung-Su
Cho Jae-Youl
Park Ji-Soo
Lee Jae-Ho
Yoo Eun-Sook
Baik Kyong-Up
Lee Jong-Soo
Park Myung-Hwan
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Abstract
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Three TNF-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF- production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (
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KEYWORD
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Magnolia fargesii, bioassay-guided isolation, flower buds, lignans, TNF-α, murine macrophage cell line
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